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Prox1tm1Gco
Targeted Allele Detail
Summary
Symbol: Prox1tm1Gco
Name: prospero homeobox 1; targeted mutation 1, Guillermo Oliver
MGI ID: MGI:2386336
Synonyms: Prox1-, ProxLacZ
Gene: Prox1  Location: Chr1:189850232-189902911 bp, - strand  Genetic Position: Chr1, 95.85 cM
Alliance: Prox1tm1Gco page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53431
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA cassette containing lacZ and neo was fused in frame at the codon 224. Expression of beta-galactosidase was driven by the endogenous promoter. (J:53431)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 118 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 13 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prox1 Mutation:  43 strains or lines available
Notes

In J:53431, the original chimeric mice were crossed to four different genetic backgrounds. In three (unspecified) backgrounds mortality was 100% penetrant, whereas crosses to the NMRI background produced some surviving heterozygotes, which were used to generate homozygous embryos.

References
Original:  J:53431 Wigle JT, et al., Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet. 1999 Mar;21(3):318-22
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory