Tg(TcrHEL3A9)1Mmd
Transgene Detail
|
|
| Symbol: |
Tg(TcrHEL3A9)1Mmd |
| Name: |
transgene insertion 1, Mark M Davis |
| MGI ID: |
MGI:2385683 |
| Synonyms: |
3A9 anti-HEL, 3A9 TCR, Tg(TcrHEL3A9)Mmd |
| Transgene: |
Tg(TcrHEL3A9)1Mmd Location: unknown
|
| Alliance: |
Tg(TcrHEL3A9)1Mmd page
|
|
|
|
| Transgene Type: |
|
Transgenic (Inserted expressed sequence) |
| Mutation: |
|
Insertion
|
| |
|
Tg(TcrHEL3A9)1Mmd expresses
2 genes
|
| |
|
Mutation details: Transgenic mice produced from this construct carry transgenes encoding the T cell receptor alpha and beta (Tcra and Tcrb, respectively) chains from the hen egg lysozyme (HEL)-specific T cell hybridoma 3A9. Two vectors were constructed and subsequently co-injected into C57BL/6J eggs. The first vector contained the Tcra variable and joining regions (V and J, respectively) and a 3.5kb segment 3' to the Tcra constant region. The second vector contained the Tcrb variable, diversity, and joining regions (V, D, and J, respectively) and a 7.5kb segment 3' to the Tcrb constant region, which included the Tcrb enhancer region. Transgenic mice expressed the alpha and beta chains of a T cell receptor specific for hen egg lysozyme. Two female founders were generated.
(J:73608)
|
| Inheritance: |
|
Not Specified |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 6 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:73608 Ho WY, et al., Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells. J Exp Med. 1994 May 1;179(5):1539-49 |
| All: |
58 reference(s) |
|
Analysis Tools
