Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fgf17tm1Dor
Name:	fibroblast growth factor 17; targeted mutation 1, David M Ornitz
MGI ID:	MGI:2385594
Synonyms:	Fgf17-, Fgf17neo
Gene:	Fgf17  Location: Chr14:70873643-70879708 bp, - strand  Genetic Position: Chr14, 36.4 cM
Alliance:	Fgf17tm1Dor page

Germline Transmission:	Earliest citation of germline transmission: J:61429
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A contstruct, in which the translational start site and two exons encoding the signal peptide were replaced by cre and neo genes, was inserted at the endogenous locus by homologous recombination. In situ hybridization showed a lack of transcript at the midbrain-hindbrain junction in homozygous mutant mice. Expression of Cre recombinase was not reported. (J:61429)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgf17 Mutation:	34 strains or lines available

Original:	J:61429 Xu J, et al., Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Development. 2000 May;127(9):1833-43
All:	11 reference(s)