Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Men1tm1Gfk
Name:	multiple endocrine neoplasia 1; targeted mutation 1, Graham F Kay
MGI ID:	MGI:2384620
Synonyms:	FE2, Men1loxP
Gene:	Men1  Location: Chr19:6385009-6390921 bp, + strand  Genetic Position: Chr19, 4.45 cM, cytoband A
Alliance:	Men1tm1Gfk page

Germline Transmission:	Earliest citation of germline transmission: J:75116
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129T2/SvEms

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A construct, in which Exon 2 was flanked by a loxP site inserted into intron 1 and a floxed neo cassette ineserted into intron 2, was incorporated at the endogenous locus by homologous recombination. (J:75116)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Men1tm1Gfk

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Men1 Mutation:	40 strains or lines available

Original:	J:75116 Biondi C, et al., Targeting and conditional inactivation of the murine Men1 locus using the Cre recombinase: loxP System. Genesis. 2002 Feb;32(2):150-1
All:	4 reference(s)