Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Nrp2tm1.2Mom
Name:	neuropilin 2; targeted mutation 1.2, Peter Mombaerts
MGI ID:	MGI:2183904
Synonyms:	Neuropilin-2-Delta, NP2-delta, Nrp2del, Nrp2taugfp, Nrp2tm1Mom
Gene:	Nrp2  Location: Chr1:62742476-62857851 bp, + strand  Genetic Position: Chr1, 31.35 cM, cytoband C2
Alliance:	Nrp2tm1.2Mom page

Germline Transmission:	Earliest citation of germline transmission: J:76686
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site 272 bp upstream of the translation initiation codon was introduced into exon 1 and a loxP-tauGFP FRT-flanked neo cassette was inserted 1 kb into intron 1 via homologous recombination. Heterozygous animals were crossed to an flp recombinase transgenic line for removal of the neo cassette. Subsequent mating to a cre recombinase transgenic line removed exon 1 and part of intron 1 leaving the tauGFP cassette intact. The exon 1 deletion removes the plasma membrane-targeting signal sequence and also brings the tauGFP cassette under the control of the endogenous promoter. RT-PCR analysis confirmed the removal of the signal sequence in gene transcripts from homozygous mutant animals. Immunohistochemistry of brain sections from homozygous mutants did not detect protein product. (J:76686)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	45 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrp2 Mutation:	88 strains or lines available

Original:	J:76686 Walz A, et al., Aberrant sensory innervation of the olfactory bulb in neuropilin-2 mutant mice. J Neurosci. 2002 May 15;22(10):4025-35
All:	15 reference(s)