Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Acta1tm1Jll
Name:	actin alpha 1, skeletal muscle; targeted mutation 1, James L Lessard
MGI ID:	MGI:2183817
Gene:	Acta1  Location: Chr8:124618508-124621490 bp, - strand  Genetic Position: Chr8, 72.26 cM
Alliance:	Acta1tm1Jll page

Germline Transmission:	Earliest citation of germline transmission: J:78070
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 2 was disrupted by the insertion of an hprt minigene. Northern blot analysis of total RNA obtained from limbs showed an absence of transcript in homozygous mutant mice. (J:78070)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acta1 Mutation:	14 strains or lines available

Original:	J:78070 Crawford K, et al., Mice lacking skeletal muscle actin show reduced muscle strength and growth deficits and die during the neonatal period. Mol Cell Biol. 2002 Aug;22(16):5887-96
All:	4 reference(s)