Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Agtr1atm2Tma
Name:	angiotensin II receptor, type 1a; targeted mutation 2, Taiji Matsusaka
MGI ID:	MGI:2183543
Synonyms:	Agtr1a-, Agtr1agfp
Gene:	Agtr1a  Location: Chr13:30520424-30566850 bp, + strand  Genetic Position: Chr13, 13.19 cM
Alliance:	Agtr1atm2Tma page

Germline Transmission:	Earliest citation of germline transmission: J:36090
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 190 bp of the gene coding region was replaced with a gfp-PGK-neo cassette via homologous recombination. The gfp-PGK-neo cassette was inserted in frame after the third transmembrane domain. Northern blot analysis of kidney tissue confirmed the absence of gene expression in homozygous mutant animals. Although gfp transcripts were present in the kidneys of mutant animals, gfp activity could not be detected. (J:36090)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agtr1a Mutation:	40 strains or lines available

Original:	J:36090 Matsusaka T, et al., Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells. J Clin Invest. 1996 Oct 15;98(8):1867-77
All:	3 reference(s)