Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Plcb4tm1Dwu Name: phospholipase C, beta 4; targeted mutation 1, Dianqing Wu MGI ID: MGI:2183374 Synonyms: PLCBeta4- Gene: Plcb4  Location: Chr2:135500931-135856513 bp, + strand  Genetic Position: Chr2, 66.64 cM Alliance: Plcb4tm1Dwu page

Retinal morphology of Plcb4tm1Dwu/Plcb4tm1Dwu mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:77638
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Disruption caused by insertion of vector   Mutation details: The exon encoding the X box was disrupted by the insertion of a neomycin selection cassette. Encoded protein was undetected in retinal extracts and brain sections via Western blot analysis and immunohistochemical staining, respectively. (J:77638)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plcb4 Mutation:	130 strains or lines available

Original:	J:77638 Jiang H, et al., Phospholipase C beta 4 is involved in modulating the visual response in mice. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14598-601
All:	7 reference(s)