Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Calrtm1Star
Name:	calreticulin; targeted mutation 1, Rene St-Arnaud
MGI ID:	MGI:2183263
Synonyms:	CRT-
Gene:	Calr  Location: Chr8:85568717-85573560 bp, - strand  Genetic Position: Chr8, 41.21 cM
Alliance:	Calrtm1Star page

Germline Transmission:	Earliest citation of germline transmission: J:61550
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a reverse-facing PGK-neo cassette into exon 1 via homologous recombination. Southern blot analysis detected homozygous mutant embryos up to E14.5. Western blot analysis of E14.5 homozygous mutant embryos verified the absence of gene expression. (J:61550)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Calr Mutation:	13 strains or lines available

Original:	J:61550 Rauch F, et al., Heart, brain, and body wall defects in mice lacking calreticulin. Exp Cell Res. 2000 Apr 10;256(1):105-11
All:	2 reference(s)