Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Siah1atm1Ddlb
Name:	siah E3 ubiquitin protein ligase 1A; targeted mutation 1, David D L Bowtell
MGI ID:	MGI:2183245
Synonyms:	Siah1a-
Gene:	Siah1a  Location: Chr8:87450635-87472562 bp, - strand  Genetic Position: Chr8, 42.1 cM
Alliance:	Siah1atm1Ddlb page

Germline Transmission:	Earliest citation of germline transmission: J:75489
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Most of the coding region of the gene was replaced with a PGK-neo cassette facing the opposite orientation via homologous recombination leaving the first 22 codons intact. Northern blot analysis using a probe to the coding region showed decreased expression in the brain and almost no expression in testes of homozygous mutant animals. The low level of transcript detected is presumed to be Siah1b, which also hybridizes to the probe. (J:75489)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Siah1a Mutation:	15 strains or lines available

Original:	J:75489 Dickins RA, et al., The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice. Mol Cell Biol. 2002 Apr;22(7):2294-303
All:	7 reference(s)