Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cyp4a14tm1Jhc
Name:	cytochrome P450, family 4, subfamily a, polypeptide 14; targeted mutation 1, Jorge H Capdevila
MGI ID:	MGI:2183240
Synonyms:	4a14(-)
Gene:	Cyp4a14  Location: Chr4:115343397-115353339 bp, - strand  Genetic Position: Chr4, 53.04 cM
Alliance:	Cyp4a14tm1Jhc page

Germline Transmission:	Earliest citation of germline transmission: J:77631
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 10 and 11, encoding the heme-binding domain, were replaced with a neomycin selection cassette. The insertion introduced a frameshift mutation at codon 404 and generated a unique HindIII restriction site. (J:77631)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp4a14 Mutation:	42 strains or lines available

Original:	J:77631 Holla VR, et al., Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5211-6
All:	8 reference(s)