Enpeptm1Mdc
Targeted Allele Detail
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| Symbol: |
Enpeptm1Mdc |
| Name: |
glutamyl aminopeptidase; targeted mutation 1, Max D Cooper |
| MGI ID: |
MGI:2182774 |
| Synonyms: |
APA-, BP-1- |
| Gene: |
Enpep Location: Chr3:129062824-129126369 bp, - strand Genetic Position: Chr3, 57.92 cM
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| Alliance: |
Enpeptm1Mdc page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:47424
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| Parent Cell Line: |
E14 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Portions of exon 1 and intron 1 were replaced by a neomycin selection cassette. Normal protein was undetected in homozygous mutant mice via flow cytometric analysis of bone marrow cells and staining of kidney sections. An assay of bone marrow cell culture supernatents showed no aberrant secretion of any protein product that could have been produced by targeted allele. Assays of renal cells, intestinal enterocytes, and stimulated bone marrow cells confirmed the ablation of aminopeptidase activity.
(J:47424)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Enpep Mutation: |
70 strains or lines available
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| Original: |
J:47424 Lin Q, et al., T and B cell development in BP-1/6C3/aminopeptidase A-deficient mice. J Immunol. 1998 May 15;160(10):4681-7 |
| All: |
7 reference(s) |
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Analysis Tools
