Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Agfg1tm1Jvd
Name:	ArfGAP with FG repeats 1; targeted mutation 1, Jan M A van Deursen
MGI ID:	MGI:2182772
Synonyms:	Hrb-
Gene:	Agfg1  Location: Chr1:82817204-82878903 bp, + strand  Genetic Position: Chr1, 42.55 cM, cytoband C5
Alliance:	Agfg1tm1Jvd page

Germline Transmission:	Earliest citation of germline transmission: J:72756
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A 500 bp region of the gene was replaced with a promoter-less IRES-lacZ-neo cassette via homologous recombination resulting in disruption of the gene at amino acid 108. Absence of gene expression in various tissues from homozygous mutant animals was verified by Western blot analysis. (J:72756)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agfg1 Mutation:	46 strains or lines available

Original:	J:72756 Kang-Decker N, et al., Lack of acrosome formation in hrb-deficient mice. Science. 2001 Nov 16;294(5546):1531-3
All:	5 reference(s)