Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tmiesr-J
Name:	transmembrane inner ear; spinner Jackson
MGI ID:	MGI:2182706
Synonyms:	srJ
Gene:	Tmie  Location: Chr9:110694755-110709141 bp, - strand  Genetic Position: Chr9, 60.79 cM
Alliance:	Tmiesr-J page

Strain of Origin:

BXA4/PgnJ

Allele Type:    Spontaneous Mutation:    Single point mutation   Mutation details: A single nucleotide C-toT substitution in exon 5 produced a nonsense mutation at arginine codon 97 (p.R97*) that will prevent expression of the majority of the C-terminal charged domain. (J:78124) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tmie Mutation:	15 strains or lines available

Original:	J:78124 Mitchem KL, et al., Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6. Hum Mol Genet. 2002 Aug 1;11(16):1887-98
All:	2 reference(s)