Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Drgxtm1And
Name:	dorsal root ganglia homeobox; targeted mutation 1, David J Anderson
MGI ID:	MGI:2182636
Synonyms:	Drg11-, Prrxl1-
Gene:	Drgx  Location: Chr14:32321364-32371203 bp, + strand  Genetic Position: Chr14, 19.4 cM
Alliance:	Drgxtm1And page

Germline Transmission:	Earliest citation of germline transmission: J:70560
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 3 and 4 were replaced with a IRES-Tau-lacZ-neo cassette via homologous recombination. The gene targeting event results in deletion of most of the paired-like homeodomain and putative DNA-binding domain. RT-PCR analysis of homozygous mutant animals was unable to detect gene transcription using primers to the gene coding region or neomycin resistance gene. Amplification products were obtained using primers to the lacZ gene, but lack of beta-gal activity suggests these transcripts were spliced abnormally. (J:70560)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Drgx Mutation:	11 strains or lines available

Original:	J:70560 Chen Z, et al., The paired homeodomain protein drg11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron. 2001 Jul 19;31(1):59-73
All:	8 reference(s)