Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Efna5tm1Ddmo
Name:	ephrin A5; targeted mutation 1, Dennis D M O'Leary
MGI ID:	MGI:2182573
Synonyms:	A5-, eA5KO, Efna5-, ephrin-A5-
Gene:	Efna5  Location: Chr17:62911179-63188312 bp, - strand  Genetic Position: Chr17, 32.57 cM
Alliance:	Efna5tm1Ddmo page

Germline Transmission:	Earliest citation of germline transmission: J:45896
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced sequence encoding amino acids 42 through 129 as well as a 5' splice acceptor. RT-PCR analysis showed an absence of transcript in homozygous mutant mice. (J:45896)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Efna5 Mutation:	28 strains or lines available

Original:	J:45896 Frisen J, et al., Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Neuron. 1998 Feb;20(2):235-43
All:	57 reference(s)