Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ctsgtm1.1Roes
Name:	cathepsin G; targeted mutation 1.1, Jurgen Roes
MGI ID:	MGI:2182170
Synonyms:	CG-
Gene:	Ctsg  Location: Chr14:56337342-56340031 bp, - strand  Genetic Position: Chr14, 28.19 cM
Alliance:	Ctsgtm1.1Roes page

Germline Transmission:	Earliest citation of germline transmission: J:77597
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Transient expression of cre recombinase in ES cells resulted in the excision of a floxed neomycin cassette and a deletion spanning exons 2, 3, and part of 4. Northern and Western blot analyses of bone marrow cells showed an absence of transcript and protein in homozygous mutant mice. (J:77597)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Ctsg Mutation:	13 strains or lines available

Original:	J:77597 Tkalcevic J, et al., Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity. 2000 Feb;12(2):201-10
All:	7 reference(s)