Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lta4htm1Bhk
Name:	leukotriene A4 hydrolase; targeted mutation 1, Beverly H Koller
MGI ID:	MGI:2182082
Synonyms:	LtA4 hydrolase-
Gene:	Lta4h  Location: Chr10:93289273-93320737 bp, + strand  Genetic Position: Chr10, 48.42 cM, cytoband C3
Alliance:	Lta4htm1Bhk page

Germline Transmission:	Earliest citation of germline transmission: J:58985
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced 114 base pairs of coding sequence. Northern blot analysis of total RNA showed an absence of transcript in bone marrow and bone marrow mast cells, both obtained from homozygous mutant mice. (J:58985)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lta4h Mutation:	28 strains or lines available

Original:	J:58985 Byrum RS, et al., Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice. J Immunol. 1999 Dec 15;163(12):6810-9
All:	15 reference(s)