Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bace1tm1.1Slr
Name:	beta-site APP cleaving enzyme 1; targeted mutation 1.1, Steven L Roberds
MGI ID:	MGI:2181644
Synonyms:	BACE-, exon 4-8-deleted
Gene:	Bace1  Location: Chr9:45749878-45775694 bp, + strand  Genetic Position: Chr9, 25.22 cM
Alliance:	Bace1tm1.1Slr page

Germline Transmission:	Earliest citation of germline transmission: J:77414
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This allele was generated by breeding mice heterozygous for Bacetm1Slr and transgenic mice constituitively expressing FLP recombinase. Exons 4 through 8 as well as the neomycin selection cassette and the FLP recombinase target (FRT) sites flanking it were excised. The deleted exons encoded two active site aspartate residues. One FRT site remained in intron 8. Beta-secretase activity was undetected in extracts of cortical cell cultures derived from homozygous mutant animals. (J:77414)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bace1 Mutation:	27 strains or lines available

Original:	J:77414 Roberds SL, et al., BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet. 2001 Jun 1;10(12):1317-24
All:	4 reference(s)