Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Nr1h3tm1Djm
Name:	nuclear receptor subfamily 1, group H, member 3; targeted mutation 1, David J Mangelsdorf
MGI ID:	MGI:2181380
Synonyms:	LXRalpha (-), Nr1h3-
Gene:	Nr1h3  Location: Chr2:91014406-91033179 bp, - strand  Genetic Position: Chr2, 50.52 cM
Alliance:	Nr1h3tm1Djm page

Germline Transmission:	Earliest citation of germline transmission: J:47971
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 3-6 encoding the DNA-binding and ligand-binding domains (amino acids 87-327) were replaced with a neomycin resistance gene via homologous recombination. Northern blot and Western blot analysis of liver from homozygous mutant animals verified the absence of mRNA and protein expression. (J:47971)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nr1h3 Mutation:	32 strains or lines available

Original:	J:47971 Peet DJ, et al., Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 1998 May 29;93(5):693-704
All:	108 reference(s)