Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arl4atm1Asch
Name:	ADP-ribosylation factor-like 4A; targeted mutation 1, A Schurmann
MGI ID:	MGI:2181269
Synonyms:	Arl4-
Gene:	Arl4a  Location: Chr12:40083290-40087986 bp, - strand  Genetic Position: Chr12, 18.06 cM
Alliance:	Arl4atm1Asch page

Germline Transmission:	Earliest citation of germline transmission: J:75778
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 of the gene was replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis confirmed the absence of mRNA transcripts from testis, spleen, and intestine of homozygous mutant animals, and immunohistochemical analysis of testes sections demonstrated the absence of protein product. (J:75778)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arl4a Mutation:	7 strains or lines available

Original:	J:75778 Schurmann A, et al., Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene. Mol Cell Biol. 2002 Apr;22(8):2761-8
All:	1 reference(s)