Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Csf2rbtm1Cgb
Name:	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); targeted mutation 1, C Glenn Begley
MGI ID:	MGI:2181245
Synonyms:	Beta-c-, Betac-, GM-CSFR-
Gene:	Csf2rb  Location: Chr15:78210000-78235201 bp, + strand  Genetic Position: Chr15, 37.36 cM
Alliance:	Csf2rbtm1Cgb page

Germline Transmission:	Earliest citation of germline transmission: J:29737
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 7 was disrupted by the insertion of a neomycin selection cassette that introduced stop codons into all three reading frames. A binding assay of homozygous bone marrow cells showed that high affinity binding of the colony stimulating factor was ablated. Binding of interleukin 3 was unaffected in cells isolated from mutant mice, indicating that the homologous interleukin 3 receptor was not affected by the targeting event. (J:29737)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Csf2rb Mutation:	47 strains or lines available

Original:	J:29737 Robb L, et al., Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9565-9
All:	53 reference(s)