Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd48tm1Rsr
Name:	CD48 antigen; targeted mutation 1, Hans Reiser
MGI ID:	MGI:2180770
Synonyms:	CD48-
Gene:	Cd48  Location: Chr1:171509577-171532826 bp, + strand  Genetic Position: Chr1, 79.54 cM
Alliance:	Cd48tm1Rsr page

Germline Transmission:	Earliest citation of germline transmission: J:53718
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced the exon encoding the immunoglobulin-V-like domain, which forms a binding site for the Cd2 antigen. Thymocytes and splenocytes isolated from homozygous mutant mice were found to lack surface expression of the endogenous protien. (J:53718)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd48 Mutation:	22 strains or lines available

Original:	J:53718 Gonzalez-Cabrero J, et al., CD48-deficient mice have a pronounced defect in CD4(+) T cell activation. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1019-23
All:	6 reference(s)