Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Bub3tm1Khac
Name:	BUB3 mitotic checkpoint protein; targeted mutation 1, K H Andy Choo
MGI ID:	MGI:2180502
Synonyms:	Bub3-
Gene:	Bub3  Location: Chr7:131162081-131173625 bp, + strand  Genetic Position: Chr7, 74.36 cM
Alliance:	Bub3tm1Khac page

Germline Transmission:	Earliest citation of germline transmission: J:64874
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3 were replaced with a lacZ-neomycin fusion gene lacking a promoter but possessing a splice acceptor site and an internal ribosome entry site (IRES). The authors believed that only the first 65 amino acids would be translated, producing a protein lacking three of the four WD40 domains as well as the protein-interacting kinetochore domain. (J:64874)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bub3 Mutation:	23 strains or lines available

Original:	J:64874 Kalitsis P, et al., Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. Genes Dev. 2000 Sep 15;14(18):2277-82
All:	2 reference(s)