Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Atp2a3tm1Ges
Name:	ATPase, Ca++ transporting, ubiquitous; targeted mutation 1, Gary E Shull
MGI ID:	MGI:2180376
Synonyms:	SERCA3-
Gene:	Atp2a3  Location: Chr11:72851995-72883869 bp, + strand  Genetic Position: Chr11, 45.0 cM
Alliance:	Atp2a3tm1Ges page

Germline Transmission:	Earliest citation of germline transmission: J:44333
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance gene was inserted into exon 5, which encodes amino acids 109 through 154. Northern blot analysis of RNA isolated from colon, lung, and aorta tissue showed the presence of a shortened transcript in homozygous mutant mice. Sequence analysis of the mutant message identified a cryptic donor site in exon 5 that led to the excision of 84 nucleotides encoding amino acids 127 through 154. Transfection of microsomes, showed that the mutant protein product was incapable of calcium-uptake. (J:44333)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atp2a3 Mutation:	35 strains or lines available

Original:	J:44333 Liu LH, et al., Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+-ATPase isoform 3. J Biol Chem. 1997 Nov 28;272(48):30538-45
All:	6 reference(s)