Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Asgr1tm1Ishi
Name:	asialoglycoprotein receptor 1; targeted mutation 1, Shun Ishibashi
MGI ID:	MGI:2180369
Synonyms:	MHL-1 -
Gene:	Asgr1  Location: Chr11:69944911-69948720 bp, + strand  Genetic Position: Chr11, 42.98 cM
Alliance:	Asgr1tm1Ishi page

Germline Transmission:	Earliest citation of germline transmission: J:68876
Parent Cell Line:	JH1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene under the control of a pol2 promoter replaced the transcription initiation codon and the sequences encoding the transmembrane domain. Northern blot analysis showed an absence of normal transcipt in homozygous mutant mice. A truncated message was detected, however, Western blot analysis showed there to be no protein expression in homozygous mutant animals. (J:68876)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Asgr1 Mutation:	15 strains or lines available

Original:	J:68876 Tozawa R, et al., Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit. Its obligate requirement for the stable expression of oligomeric receptor. J Biol Chem. 2001 Apr 20;276(16):12624-8
All:	3 reference(s)