Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cacna1dtm1Hssh
Name:	calcium channel, voltage-dependent, L type, alpha 1D subunit; targeted mutation 1, Hee-Sup Shin
MGI ID:	MGI:2180138
Synonyms:	alpha(1D)-, Cav1.3-
Gene:	Cacna1d  Location: Chr14:29761898-30213113 bp, - strand  Genetic Position: Chr14, 18.43 cM, cytoband B
Alliance:	Cacna1dtm1Hssh page

Germline Transmission:	Earliest citation of germline transmission: J:72316
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 1 and all of exon 2 was replaced with an IRES-BetaGal-polyA-PGK-neo cassette via homologous recombination. Western blot of cerebral membrane fractions and immunohistochemical staining of pancreas sections from homozygous mutant animals did not detect protein product. Unexpectedly, lacZ staining was not detected in mutant animals. (J:72316)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1d Mutation:	119 strains or lines available

Original:	J:72316 Namkung Y, et al., Requirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generation. J Clin Invest. 2001 Oct;108(7):1015-22
All:	7 reference(s)