Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aebp1tm1Mdl
Name:	AE binding protein 1; targeted mutation 1, Matthew D Layne
MGI ID:	MGI:2180115
Synonyms:	ACLP-
Gene:	Aebp1  Location: Chr11:5811947-5822088 bp, + strand  Genetic Position: Chr11, 3.88 cM
Alliance:	Aebp1tm1Mdl page

Germline Transmission:	Earliest citation of germline transmission: J:70416
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neo cassette was used to replace exons 7 through the majority of 16. The deleted region encodes the discoidin domain and a portion of the carboxypeptidase-like domain. Northern and Western analyses of homozygous embryos showed an absence of normal mRNA and protein expression, respectively. Because the antiserum used for the Western analysis was raised against the C-terminus, it is possible that a truncated protein was present in heterozygous mutants, though the authors believe that there is no gain-of-function. (J:70416)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aebp1 Mutation:	32 strains or lines available

Original:	J:70416 Layne MD, et al., Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein. Mol Cell Biol. 2001 Aug;21(15):5256-61
All:	4 reference(s)