Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Abcb1atm1Bor
Name:	ATP-binding cassette, sub-family B member 1A; targeted mutation 1, Piet Borst
MGI ID:	MGI:2180054
Synonyms:	mdr1a-
Gene:	Abcb1a  Location: Chr5:8710077-8798575 bp, + strand  Genetic Position: Chr5, 3.43 cM
Alliance:	Abcb1atm1Bor page

Germline Transmission:	Earliest citation of germline transmission: J:18554
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1.6-kb fragment containing exons 6 and 7 and encoding the extracellular, transmembrane, and cytoplasmic domains, was replaced by the insertion of a hygromycin cassette. While low levels of transcript were detected in the intestines of homozygous mutant mice by RNAase protection assays, immunoblot analysis showed an absence of protein expression. (J:18554)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

List all tumor models in MMHCdb carrying Abcb1atm1Bor

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Abcb1a Mutation:	93 strains or lines available

Original:	J:18554 Schinkel AH, et al., Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell. 1994 May 20;77(4):491-502
All:	111 reference(s)