Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Nr5a1tm2Klp
Name:	nuclear receptor subfamily 5, group A, member 1; targeted mutation 2, Keith L Parker
MGI ID:	MGI:2180013
Synonyms:	F, Sf1Fl
Gene:	Nr5a1  Location: Chr2:38582668-38604554 bp, - strand  Genetic Position: Chr2, 24.42 cM
Alliance:	Nr5a1tm2Klp page

Germline Transmission:	Earliest citation of germline transmission: J:66593
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A single loxP site was inserted into an intron 5' to the last coding exon, and a loxP site followed by a neomycin resistance cassette was inserted 3' to this exon. This mutation flanks sequences encoding motifs essential for transcriptional activity as well as the transcription termination and polyadenyulation sequences. (J:66593)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	28 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	26 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nr5a1 Mutation:	30 strains or lines available

Original:	J:66593 Zhao L, et al., Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function. Development. 2001 Jan;128(2):147-54
All:	25 reference(s)