Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arhgap5tm1Jset
Name:	Rho GTPase activating protein 5; targeted mutation 1, Jeffrey Settleman
MGI ID:	MGI:2179998
Synonyms:	p190 B RhoGAP-
Gene:	Arhgap5  Location: Chr12:52550755-52618758 bp, + strand  Genetic Position: Chr12, 22.16 cM
Alliance:	Arhgap5tm1Jset page

Germline Transmission:	Earliest citation of germline transmission: J:76484
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A PGK-neo cassette is inserted in reverse transcriptional orientation relative to the coding sequence, disrupting the gene immediately upstream of the GTPase domain. Immunoblot of embryonic tissue probed with antisera failed to detect protein in homozygous mutant animals. (J:76484)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgap5 Mutation:	43 strains or lines available

Original:	J:76484 Sordella R, et al., Modulation of CREB Activity by the Rho GTPase Regulates Cell and Organism Size during Mouse Embryonic Development. Dev Cell. 2002 May;2(5):553-65
All:	8 reference(s)