Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ank3tm1Bnt
Name:	ankyrin 3, epithelial; targeted mutation 1, Vann Bennett
MGI ID:	MGI:2179751
Synonyms:	Ank3 exon 1b-, ankG-, cs-AnkG-KO
Gene:	Ank3  Location: Chr10:69234608-69863266 bp, + strand  Genetic Position: Chr10, 36.1 cM
Alliance:	Ank3tm1Bnt page

Germline Transmission:	Earliest citation of germline transmission: J:51377
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 1b, which is an alternatively spliced exon found in transcripts only in brain. Northern blot analysis on RNA derived from homozygous brains demonstrated that no transcript containing exon 1b was expressed, while expression of transcripts containing other alternaltively spliced exons remained unaffected. Western blot analysis and immunohistochemistry experiments confirmed that little or no protein was seen in cerebellum. (J:51377)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ank3 Mutation:	168 strains or lines available

Original:	J:51377 Zhou D, et al., AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. J Cell Biol. 1998 Nov 30;143(5):1295-304
All:	10 reference(s)