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Gsntm1Djk
Targeted Allele Detail
Summary
Symbol: Gsntm1Djk
Name: gelsolin; targeted mutation 1, David J Kwiatkowski
MGI ID: MGI:2179509
Gene: Gsn  Location: Chr2:35146392-35197904 bp, + strand  Genetic Position: Chr2, 23.5 cM
Alliance: Gsntm1Djk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:24346
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into the first coding exon, 60 bp downstream of the initiation codon. Northern blot analysis on RNA derived from various tissues of homozygous mice demonstrated that no transcript was produced from this allele. Activity assays and western blotting experiments confirmed that no functional protein was expressed. (J:24346)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 16 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Gsn Mutation:  45 strains or lines available
References
Original:  J:24346 Witke W, et al., Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell. 1995 Apr 7;81(1):41-51
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory