Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Agtr2tm1Tin Name: angiotensin II receptor, type 2; targeted mutation 1, Tadashi Inagami MGI ID: MGI:2178475 Synonyms: AT2-, AT2 KO, AT2-KO, AT2R-, AT2tm1ti Gene: Agtr2  Location: ChrX:21350863-21355072 bp, + strand  Genetic Position: ChrX, 16.71 cM Alliance: Agtr2tm1Tin page

Enhanced bone mass in Agtr2tm1Tin/Y mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:29457
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a fragment of exon 3 containing most of the coding region of the gene. Northern blot analysis on RNA derived from E17 hemizygous male embryos or adult hemizygous male brain demonstrated that no transcript was expressed from this allele. (J:29457)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	29 anatomical structure(s)

List all tumor models in MMHCdb carrying Agtr2tm1Tin

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agtr2 Mutation:	11 strains or lines available

Original:	J:29457 Ichiki T, et al., Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature. 1995 Oct 26;377(6551):748-50
All:	65 reference(s)