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Gria1tm1Rsp
Targeted Allele Detail
Summary
Symbol: Gria1tm1Rsp
Name: glutamate receptor, ionotropic, AMPA1 (alpha 1); targeted mutation 1, Rolf Sprengel
MGI ID: MGI:2178057
Synonyms: GluA1-, GluR1-, GluR-A-, GluRA-
Gene: Gria1  Location: Chr11:56902342-57221070 bp, + strand  Genetic Position: Chr11, 34.51 cM
Alliance: Gria1tm1Rsp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55695
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA single loxP site was inserted into intron 10 and a loxP flanked neomycin selection cassette was inserted into exon 11. The loxP-flanked sequences were deleted in ES cells by transient Cre expression prior to the production of chimeric mice. The final heritable allele contains a single loxP site replacing exon 11 and flanking intronic sequences. Immunohistochemistry experiments confirmed that no detectable protein is expressed from this allele. (J:55695)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gria1 Mutation:  62 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Schizoaffective Disorder (J:167264).
References
Original:  J:55695 Zamanillo D, et al., Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning [see comments]. Science. 1999 Jun 11;284(5421):1805-11
All:  59 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory