Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Etv6tm1Sho
Name:	ets variant 6; targeted mutation 1, Stuart H Orkin
MGI ID:	MGI:2177950
Synonyms:	TEL -
Gene:	Etv6  Location: Chr6:134012663-134247121 bp, + strand  Genetic Position: Chr6, 64.58 cM, cytoband G2
Alliance:	Etv6tm1Sho page

Germline Transmission:	Earliest citation of germline transmission: J:42409
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a DNA segment that contains exons coding for the DNA-binding domain. Northern blot and RT-PCR analysis on RNA derived from double-targeted ES cells demonstrated that no detectable transcript was produced from this allele. (J:42409)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Etv6 Mutation:	142 strains or lines available

Original:	J:42409 Wang LC, et al., Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. EMBO J. 1997 Jul 16;16(14):4374-83
All:	2 reference(s)