Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Eif4ebp1tm1Nso
Name:	eukaryotic translation initiation factor 4E binding protein 1; targeted mutation 1, Nahum Sonenberg
MGI ID:	MGI:2177923
Synonyms:	4E-BP1 KO, Eif4ebp1-
Gene:	Eif4ebp1  Location: Chr8:27750355-27765684 bp, + strand  Genetic Position: Chr8, 15.95 cM, cytoband A4-B1
Alliance:	Eif4ebp1tm1Nso page

Germline Transmission:	Earliest citation of germline transmission: J:72217
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The splice acceptor site and the first 57 nucleotides of exon 2 were replaced with the neomycin-resistance gene. The disrupted portion of exon 2 encodes amino acids 47 to 66, which encompasses the binding site for EIF4E. (J:72217)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

List all tumor models in MMHCdb carrying Eif4ebp1tm1Nso

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Eif4ebp1 Mutation:	33 strains or lines available

Original:	J:72217 Tsukiyama-Kohara K, et al., Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med. 2001 Oct;7(10):1128-32
All:	44 reference(s)