Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adcyap1tm1Eid
Name:	adenylate cyclase activating polypeptide 1; targeted mutation 1, Lee E Eiden
MGI ID:	MGI:2159730
Synonyms:	PACAP-
Gene:	Adcyap1  Location: Chr17:93506448-93513967 bp, + strand  Genetic Position: Chr17, 60.67 cM
Alliance:	Adcyap1tm1Eid page

Germline Transmission:	Earliest citation of germline transmission: J:73702
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced the ORF. Immunohistochemical studies of hypothalamus and IML of spinal cord did not detect protein in homozygous mice. Quantitative RT-PCR studies of hypothalamus and spinal cord did not detect mRNA in homozygous mutant mice. (J:73702)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcyap1 Mutation:	22 strains or lines available

Original:	J:73702 Hamelink C, et al., Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):461-6
All:	11 reference(s)