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Mia2 Gene Detail
Summary
  • Symbol
    Mia2
  • Name
    MIA SH3 domain ER export factor 2
  • Synonyms
    Ctage5, D12Bwg0579e, MEA6, Mgea, Mgea6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159614
    NCBI Gene: 338320
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:59142368-59237006 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 26.00 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    515 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159614
 protein coding gene Chr12:59142368-59238369 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019770
 protein coding gene Chr12:58298611-58394905 (+)
A/J MGP_AJ_G0019729
 protein coding gene Chr12:56204918-56271621 (+)
AKR/J MGP_AKRJ_G0019704
 protein coding gene Chr12:58004349-58067787 (+)
BALB/cJ MGP_BALBcJ_G0019709
 protein coding gene Chr12:56590284-56653669 (+)
C3H/HeJ MGP_C3HHeJ_G0019514
 protein coding gene Chr12:58110440-58176831 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020161
 protein coding gene Chr12:60012183-60119410 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017781
 protein coding gene Chr12:54548472-54637906 (+)
CAST/EiJ MGP_CASTEiJ_G0019066
 protein coding gene Chr12:52953940-53055166 (+)
CBA/J MGP_CBAJ_G0019483
 protein coding gene Chr12:62254580-62331659 (+)
DBA/2J MGP_DBA2J_G0019599
 protein coding gene Chr12:56128321-56190667 (+)
FVB/NJ MGP_FVBNJ_G0019587
 protein coding gene Chr12:55361306-55461059 (+)
LP/J MGP_LPJ_G0019671
 protein coding gene Chr12:58332980-58429082 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019625
 protein coding gene Chr12:63816428-63922273 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020195
 protein coding gene Chr12:57400840-57502513 (+)
PWK/PhJ MGP_PWKPhJ_G0018832
 protein coding gene Chr12:50437013-50533175 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018626
 protein coding gene Chr12:51803917-51903177 (+)
WSB/EiJ MGP_WSBEiJ_G0019117
 protein coding gene Chr12:58007527-58070370 (+)



Homology
more
  • Human Ortholog
    CTAGE1, cutaneous T cell lymphoma-associated antigen 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTAGE1, cutaneous T cell lymphoma-associated antigen 1
  • Synonyms
    CT21.1, CT21.2, CTAGE, CTAGE-1, CTAGE-2
  • Links
    NCBI Gene ID: 64693
    neXtProt AC: NX_Q96RT6
    UniProt: Q96RT6

  • Chr Location
    18q11.2; chr18:22413599-22417915 (-)  GRCh38
  • Human Ortholog
    CTAGE6, CTAGE family member 6
  • Synonyms
    CTAGE6P
  • Links
    NCBI Gene ID: 340307
    neXtProt AC: NX_Q86UF2
    UniProt: Q86UF2

  • Chr Location
    7q35; chr7:143755089-143757696 (-)  GRCh38
  • Human Ortholog
    MIA2, MIA SH3 domain ER export factor 2
  • Synonyms
    CTAGE5, MEA6, MGEA, MGEA11, MGEA6, TALI
  • Links
    NCBI Gene ID: 4253
    neXtProt AC: NX_Q96PC5
    UniProt: Q96PC5

  • Chr Location
    14q21.1; chr14:39230231-39388522 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit decreased serum levels of cholesterol, HDL cholesterol, triglyceride, and VLDL triglyceride.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    4
  • cDNA Data
    15
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 338320 NCBI Gene Model | MGI Sequence Detail 94639 C57BL/6J ±  kb
    transcript NM_001329047 RefSeq | MGI Sequence Detail 4824 ZRU/MplStud  
    polypeptide Q91ZV0 UniProt | EBI | MGI Sequence Detail 1396 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-34039, MGI:106347, MGI:1346056
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory