Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol: Anxa7tm1Pll Name: annexin A7; targeted mutation 1, Harvey B Pollard MGI ID: MGI:2159005 Synonyms: anx7 - Gene: Anxa7  Location: Chr14:20505328-20530201 bp, - strand  Genetic Position: Chr14, 11.53 cM Alliance: Anxa7tm1Pll page

Metastatic lymphosarcoma of the thymus in Anxa7tm1Pll/Anxa7+ mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:58572
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing exon 6. Western blot analysis on pancreatic tissue lysates of homozygous mice confirmed that levels of the encoded protein were reduced in heterozygotes compared to wild-type. (J:58572)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

List all tumor models in MMHCdb carrying Anxa7tm1Pll

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Anxa7 Mutation:	38 strains or lines available

Original:	J:58572 Srivastava M, et al., Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13783-8
All:	4 reference(s)