Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Ptprstm1Dro
Name:	protein tyrosine phosphatase receptor type S; targeted mutation 1, Daniela Rotin
MGI ID:	MGI:2158734
Synonyms:	Ptprs-, PTPsigma-
Gene:	Ptprs  Location: Chr17:56719426-56783480 bp, - strand  Genetic Position: Chr17, 29.32 cM
Alliance:	Ptprstm1Dro page

Germline Transmission:	Earliest citation of germline transmission: J:53433
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: Insertion of an IRES-beta-galactosidase-neomycin cassette into an intron interrupted the coding sequence between nt 460-850 in the first 1-2 immunoglobulin repeats. Northern analysis using a rat cDNA probe encompassing most of the extracellular domain did not detect transcript in heads of one-day-old homozygous mutant mice. Immunoblot analysis of brain immunoprecipitates using an affinity purified antibody against the intracellular juxtamembrane region did not detect protein in homozygous mutant newborn mice. A beta-galactosidase fusion protein was expressed by this allele under the control of the endogenous promoter. (J:53433)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptprs Mutation:	78 strains or lines available

Original:	J:53433 Wallace MJ, et al., Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma. Nat Genet. 1999 Mar;21(3):334-8
All:	7 reference(s)