Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chrm1tm1Nmn
Name:	cholinergic receptor, muscarinic 1, CNS; targeted mutation 1, Neil M Nathanson
MGI ID:	MGI:2158709
Synonyms:	M1-, m1 deficient, M1R-
Gene:	Chrm1  Location: Chr19:8641369-8660970 bp, + strand  Genetic Position: Chr19, 5.44 cM
Alliance:	Chrm1tm1Nmn page

Germline Transmission:	Earliest citation of germline transmission: J:73591
Parent Cell Line:	REK3 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 0.3 kb genomic fragment containing 5' flanking sequence, the initiation codon and the first 165 nucleotides of coding sequence was replaced with a neomycin selection cassette. Immunohistochemistry experiments on sections of hippocampus derived from homozygous mice confirmed that no detectable protein is produced from this allele. (J:73591)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chrm1 Mutation:	26 strains or lines available

Original:	J:73591 Hamilton SE, et al., Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13311-6
All:	20 reference(s)