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Npr3tm1Unc
Targeted Allele Detail
Summary
Symbol: Npr3tm1Unc
Name: natriuretic peptide receptor 3; targeted mutation 1, University of North Carolina
MGI ID: MGI:2158355
Synonyms: Npr3tm1Smi
Gene: Npr3  Location: Chr15:11839982-11907287 bp, - strand  Genetic Position: Chr15, 5.83 cM
Alliance: Npr3tm1Unc page
Skeletal phenotypes of Npr3tm1Unc/Npr3tm1Unc mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:56058
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing sequences encoding 215 amino acids of the ligand binding domain was replaced with a neomycin selection gene. Photoaffinity labeling analysis revealed that no functional protein was made in lung plasma membranes in homozygous mice. (J:56058)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 13 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Npr3 Mutation:  46 strains or lines available
References
Original:  J:56058 Matsukawa N, et al., The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7403-8
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory