Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Atp2a2tm1Ges Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; targeted mutation 1, Gary E Shull MGI ID: MGI:2158235 Synonyms: SERCA2a-, SERCA2a knockout Gene: Atp2a2  Location: Chr5:122591576-122640288 bp, - strand  Genetic Position: Chr5, 62.38 cM, cytoband F Alliance: Atp2a2tm1Ges page

Squamous cell carcinomas and papillomas of keratinized epithelial tissues in Atp2a2tm1Ges/Atp2a2+ mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:52186
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing the promoter, transcription initiation site, the first two exons and part of the third exon was replaced with a neomycin selection cassette. (J:52186)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

15 anatomical structure(s)

List all tumor models in MMHCdb carrying Atp2a2tm1Ges

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atp2a2 Mutation:	76 strains or lines available

Original:	J:52186 Periasamy M, et al., Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene. J Biol Chem. 1999 Jan 22;274(4):2556-62
All:	19 reference(s)