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Brca2tm1.1Brn
Targeted Allele Detail
Summary
Symbol: Brca2tm1.1Brn
Name: breast cancer 2, early onset; targeted mutation 1.1, Anton Berns
MGI ID: MGI:2156644
Synonyms: Brca2delta11
Gene: Brca2  Location: Chr5:150446095-150493794 bp, + strand  Genetic Position: Chr5, 89.52 cM
Alliance: Brca2tm1.1Brn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73028
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsHomologous recombination inserted loxP sites flanking exon 11. The loxP flanked exon 11 was removed in vivo by mating mice carrying Brca2tm1Brn with mice carrying a TgN(CMV-Cre)1Cgn transgene. (J:73028)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Brca2tm1.1Brn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca2 Mutation:  132 strains or lines available
References
Original:  J:73028 Jonkers J, et al., Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet. 2001 Dec;29(4):418-25
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory