Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnrtm1Msch
Name:	tenascin R; targeted mutation 1, Melitta Schachner
MGI ID:	MGI:2154583
Synonyms:	tn-r-
Gene:	Tnr  Location: Chr1:159351339-159759299 bp, + strand  Genetic Position: Chr1, 69.03 cM, cytoband E2
Alliance:	Tnrtm1Msch page

Germline Transmission:	Earliest citation of germline transmission: J:55338
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing the coding region of exon 1 and part of intron 1 was replaced by a neomycin resistance cassette. Nothern blot and RT-PCR analysis demonstrated that an aberrant transcript is produced from this allele in total brain RNA from homozygous mice, but western blot analysis confirmed the absence of the protein in extracts derived from brains of homozygous mice. (J:55338)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnr Mutation:	65 strains or lines available

Original:	J:55338 Weber P, et al., Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS. J Neurosci. 1999 Jun 1;19(11):4245-62
All:	29 reference(s)