Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Cdk4tm1.1Bbd
Name:	cyclin dependent kinase 4; targeted mutation 1.1, Mariano Barbacid
MGI ID:	MGI:2154521
Synonyms:	Cdk4R, Cdk4R24C, Cdk4 R24C
Gene:	Cdk4  Location: Chr10:126899404-126903157 bp, + strand  Genetic Position: Chr10, 74.5 cM, cytoband D3
Alliance:	Cdk4tm1.1Bbd page

Germline Transmission:	Earliest citation of germline transmission: J:54534
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted Mutations:    Insertion, Nucleotide substitutions   Mutation details: This allele is a derivative of Cdk4tm1Bbd in which the neomycin resistance cassette was deleted via Cre-mediated recombination in the germ line. These mice express comparable levels of mutant protein to wild-type levels. (J:54534)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Cdk4tm1.1Bbd

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdk4 Mutation:	57 strains or lines available

Original:	J:54534 Rane SG, et al., Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet. 1999 May;22(1):44-52
All:	55 reference(s)