Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Elntm1Dyl Name: elastin; targeted mutation 1, Dean Y Li MGI ID: MGI:2153007 Synonyms: Eln- Gene: Eln  Location: Chr5:134731447-134776177 bp, - strand  Genetic Position: Chr5, 74.76 cM Alliance: Elntm1Dyl page

Reduced vessel extensibility in the Fbln5tm1Eno/Fbln5tm1Eno and Elntm1Dyl/Eln+ carotid artery Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:47771
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced 4kb of gene sequence. In situ hybridization analysis showed the absence of the transcript in aortae of E17.5 homozygous mutant mice. The protein was not detectable in P0.5 aortae of homozygous mutant mice by hart staining. (J:47771)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Eln Mutation:	40 strains or lines available

Original:	J:47771 Li DY, et al., Elastin is an essential determinant of arterial morphogenesis. Nature. 1998 May 21;393(6682):276-80
All:	43 reference(s)