Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Itpkatm1Hssh
Name:	inositol 1,4,5-trisphosphate 3-kinase A; targeted mutation 1, Hee-Sup Shin
MGI ID:	MGI:2152168
Gene:	Itpka  Location: Chr2:119572818-119581734 bp, + strand  Genetic Position: Chr2, 59.97 cM
Alliance:	Itpkatm1Hssh page

Germline Transmission:	Earliest citation of germline transmission: J:51150
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin cassette was inserted into the sequence at position 389 from the translation start codon. Northern blot analysis on RNA derived from brain of homozygous mice failed to detect a transcript produced from this allele, and western blot analysis demonstrated that no ITPKA protein is produced in homozygous mice. (J:51150)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itpka Mutation:	11 strains or lines available

Original:	J:51150 Jun K, et al., Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice. Learn Mem. 1998 Sep-Oct;5(4-5):317-30
All:	3 reference(s)