Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hoxc4tm1Mrc
Name:	homeobox C4; targeted mutation 1, Mario R Capecchi
MGI ID:	MGI:2150683
Gene:	Hoxc4  Location: Chr15:102927366-102945278 bp, + strand  Genetic Position: Chr15, 58.08 cM
Alliance:	Hoxc4tm1Mrc page

Germline Transmission:	Earliest citation of germline transmission: J:34198
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin cassette was inserted into the XhoI site at nucleotide 10 of the sequences encoding the homeobox domain. Immunohistochemistry studies failed to detect any protein in hemisected E12.5 homozygous embryos. (J:34198)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	26 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxc4 Mutation:	8 strains or lines available

Original:	J:34198 Boulet AM, et al., Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations. Dev Biol. 1996 Jul 10;177(1):232-49
All:	1 reference(s)